• Mike Barker (1) | voiced | Delivery Man / Terry Bates / Gordon / Various / Flower / Biology Teacher / Mannie | Chuck White / Jesus / Sanders / Terry Bates | Chuck White / Jerry / Terry Bates | Chuck White | Meter Maid / Terry Bates | Scientist / Nick / Terry Bates | Frank / Jock #2 | Pig / Terry Bates | Ticket Guy | Valet / Terry Bates | Contestant / Terry Bates | Mr. Madsen / Terry Bates | Agent Mulder / Terry Bates | Deer | Dr. Heisler / Sanders | Ron / Mugger | Zargon Cult Member #1 | Cashier | Security Guard / Tyler Johnson / CIA Lab Tech / Stone Mayhem Announcer / Wedding Guest / Zoe's Dad / Ticket Taker | 99 Episodes |
• Patrick Stewart | voiced | Bullock / Avery Bullock | 80 Episodes |
• Curtis Armstrong | voiced | Schmuley “Snot” Lonstein | 78 Episodes |
• Eddie Kaye Thomas | voiced | Barry / Barry Robinson / Barry Robinson | Flandnag / Barry Robinson | Spike Baltar / Benji | 64 Episodes |
• Jeff Fischer | voiced | Jeff Fischer / Jeff Fischer | Donnie Patterson / Various | 53 Episodes |
• Kevin Michael Richardson | voiced | TV Announcer / Principal Lewis / Principal Brian Lewis / Various / Big Monty / Principal Brian Lewis | TV Announcer / Jerry / Tank Bates / Principal Brian Lewis | Tow Truck Driver / Vitas / Theater Sweeper / Black Villian / Bum #2 / Jamaicans | 51 Episodes |
• Daisuke Suzuki | voiced | Toshi Hirano | Popo / Toshi Hirano / Asian Man | 51 Episodes |
• Mike Henry (1) | voiced | Jackson / Senator #2 / Taco / Bee / Gang Leader / Various / Jackson | Maitre D' / Faziz / Jackson | Michael Moore | Faziz / Jackson | Painter / Jackson | Taco King / Kayaker / Jackson | Strip Club Patron / Jackson | Jackson's Hooker / Cleveland Brown / Igor "The Wolf" Ruskinov | 46 Episodes |
• Matt McKenna | voiced | Buckle / Disability Check Dan / Captain Monte | Mr. Stashwick / Various / Bailliff / Jesus / Drill Sergeant / Coach Andrews / Coach Patterson / Cap'n Monty | Kevin Broham / Unknown / Zargon Cult Leader / Ghoul / Santa / Mr. Stashwick | Homeless Guy #3 / Dimitri / Detective / TV Announcer | 38 Episodes |
• Erik Durbin | voiced | Reginald / Manny / Various / Gerald / Langley Falls Town Geologist / The DJ / Crack Head BooBoo / Janitor / Randy | Zargon Cult Member #2 / Bob Todd / Philippe Monday / Lil' Turtle | 36 Episodes |
• David Koechner | voiced | Dick Reynolds / Unknown | 29 Episodes |
• Seth MacFarlane | voiced | Greg Corbin / Greg Corbin | Film Narrator / Peter Griffin / Brian Griffin / Stewie Griffin / Glenn Quagmire / Strip Club Patron / Kevin Rowland | 25 Episodes |
• Alex Cuthbertson | voiced | Kid / Various / Joel Larson | 23 Episodes |
• Chris Diamantopoulos | voiced | Donald Sutherland | Robert Deniro / Various / Sander's Double / Hanson Foam Man / Senor Hidalgo / Delorean Door Owner / Scott | Alejandro / Marvin | 22 Episodes |
• Jonathan Fener | voiced | Airline Steward / Various / Inmate / Helicopter Perry | 20 Episodes |
• André Sogliuzzo | voiced | Teacher / Johnny Depp / Various / Dill / George Clooney / Deaf Teddy | Blind Jimmy / Manager / Gabe Kaplan / Spy | Young Father / Doctor Stack | 18 Episodes |
• Judah Miller | voiced | Various / Toilet / Hitchhiker / Vince's Friend / Mick | 16 Episodes |
• Paget Brewster | voiced | Judy / Michelle / Michelle Morris / Unknown / Raina Markovitz / Casey / Thundercat / Mia / Carmen Selectra / Shapeshifter | 15 Episodes |
• Fred Tatasciore | voiced | Various / Bill Elliot | Senator / Warden / Johnny Four-Legs / Police of Vice & Virtue #2 | Judge / Police of Vice & Virtue #2 / League Official / Lieutenant Goldberg | 15 Episodes |
• Jill Talley | voiced | Cocktail Waitress | Flight Attendant | Oscar's Mother / Various / Senator Feinstein | Maria / Fat Lady / Janet Gustafson / Little Girl's Mom | Ramona / Dalia / Workshop Representative | 12 Episodes |
• Matt E. Mixer | voiced | Various | 12 Episodes |
• Rachael MacFarlane | voiced | Barbara "Barb" Hanson / Judy Panowitz / Sandy / Barbra Streisand / Gypsy / Cute Baby Pics Employee / Gertie / Nurse / Cafe Woman / HSC Host #1 / Matilda | 11 Episodes |
• Laura McCreary | voiced | Various / Stewardess / Unknown / Helen / Old Lady Singer / Jenny Johnson | 11 Episodes |
• Martin Mull | voiced | Father Donovan | 10 Episodes |
• Stephen Root | voiced | Dick / Dentist's Father / Dick Reynolds | Co-Worker #4 / Dick Reynolds | 10 Episodes |
• Erik Sommers | voiced | Various / Rivers | 10 Episodes |
• Steve Hely | voiced | Jim Henson / Frank / Wolverine Player / Sergei Kruglov / Various | 9 Episodes |
• John DiMaggio | voiced | Sergei Petkov / Car Repo Guy / Priest / Brad | Leon / Bouncer | The Dove / Various / Sully / Hitman | 9 Episodes |
• Amir Talai | voiced | Sanjay Bhudapar / Achmed Asadi / Various / Snake | 9 Episodes |
• Eric Edwards | voiced | Bagel Shop Owner / Henry Callaway / Various / Manager / Nathan / Trevor / Mikey Muskrat Mascot | 9 Episodes |
• Matt Fusfeld | voiced | Various / Majestic | 9 Episodes |
• Murray Miller | voiced | Unknown / Antichrist / Various / Toilet Paper | Toilet Brush | 8 Episodes |
• Peter MacKenzie | voiced | Dr. Grossbard / Senator #1 / Various / Unknown / Chief Shopaholic | Midnight Runner #1 | Salesman / Dr. Grossbard | Senator #1 / Nathan's Dad / Mr. Chimdale | 8 Episodes |
• John Viener | voiced | Various / Roy Family / Kobe Bryant | Male Nurse | 8 Episodes |
• Amy Hill | voiced | Mah Mah Ling | 7 Episodes |
• Marissa Jaret Winokur | voiced | Various / Ugly Girl / Jewel / MaryAnn / HSC Host #2 | 7 Episodes |
• Richard Kind | voiced | Al Tuttle | 7 Episodes |
• Nic Wegener | voiced | Various | 7 Episodes |
• Will Forte | voiced | Fake Jesus / Mayor Woodside / Various / Security Officer / Charlie Greenfield | 6 Episodes |
• Dee Bradley Baker | voiced | Grandpa Smith / Waiter / Coach Keegan / Kisses | Enormous Sea Monster / NGA Land Announcer / Little Tex | 6 Episodes |
• Daran Norris | voiced | Jack Smith | 6 Episodes |
• Swoosie Kurtz | voiced | Marilyn / Betty Smith | 6 Episodes |
• Lisa Edelstein | voiced | Sharri Rothberg | 6 Episodes |
• Asa Taccone | voiced | Various / Plunger | 6 Episodes |
• David Herman (1) | voiced | Zack / Man / Various / Arboreus | Mr. Aids | 5 Episodes |
• Scott Grimes | voiced | Blind Man / Photographer / Glass Guy #1 / Clay Aiken / Jeff Watley | 5 Episodes |
• Alan Tudyk | voiced | Various / Mr. Capellini | 5 Episodes |
• John Cho | voiced | Vince Chung | 5 Episodes |
• J.B. Smoove | voiced | Airport Security Guard / Tracy Bryant / Various | 5 Episodes |
• Niecy Nash | voiced | Patty Labelle / Angel / Lorraine | 5 Episodes |
• Sandra Oh | voiced | Mrs. Hirano / Katie | 5 Episodes |
• Megyn Price | voiced | Linda Memari | 5 Episodes |
• Scott Lowell | voiced | Felix / Brett / Barney / Various | 5 Episodes |
• Leisha Hailey | voiced | Lily / Various | 5 Episodes |
• Ari Graynor | voiced | Unknown / Various | 5 Episodes |
• Susie Essman | voiced | Unknown / Snot's Mom / Miss Lane | 5 Episodes |
• Rob Riggle | voiced | Harvey Lisle / Vic / Malcolm Hathaway / Various | 5 Episodes |
• Nick Kroll | voiced | Various / Dry Cleaner | 5 Episodes |
• Tzi Ma | voiced | Bah Bah Ling | 4 Episodes |
• Jane Lynch | voiced | Al / ObGyn Doctor / Unknown | 4 Episodes |
• Tom Hollander | voiced | Waiter | Performance Artist / Amazing Rufus / Phil / Various | 4 Episodes |
• Wendy Schaal | voiced | Delta Burke / Bernie's Mom / Mom / Patricia | 4 Episodes |
• Gregory Jbara | voiced | Plastic Surgeon / Brad Johnson / Unknown | 4 Episodes |
• Nahnatchka Khan | voiced | Various | 4 Episodes |
• Becki Newton | voiced | Unknown / Margie | 4 Episodes |
• Seth Green | voiced | Etan Cohen / Matthew McConaughey / Joey / Nat | 4 Episodes |
• Victor Raider-Wexler | voiced | Ray | 4 Episodes |
• Bob Odenkirk | voiced | Third Worker / TV Host / Mark / Various | 4 Episodes |
• Richard Gant | voiced | Various / Firefighter | 4 Episodes |
• Kevin Durand | voiced | Unknown / Bouncer / Various | 4 Episodes |
• Donald Fullilove | voiced | The Cop / Reginald | 4 Episodes |
• Wendi McLendon-Covey | voiced | Various | 4 Episodes |
• Lizzy Caplan | voiced | Debbie | 4 Episodes |
• Peter Paige | voiced | Jason / Evan / Bouncer / Various | 4 Episodes |
• Brian Boyle | voiced | Various | 4 Episodes |
• Neal Feinberg | voiced | Khalid | Zacharias | Irv Rosenblath / Khalid / Unknown | 4 Episodes |
• Charles Dennis | voiced | Michael / Unknown / Various | 4 Episodes |
• Rick Podell | voiced | Various | 4 Episodes |
• Travis Bowe | voiced | Ranch Hand / Various / Paramedic | 4 Episodes |
• Paige King | voiced | Airline Employee / Various | 4 Episodes |
• June Diane Raphael | voiced | Unknown / Various / Trish | 4 Episodes |
• Reggie Lee | voiced | Hideki Hirano / Various | 3 Episodes |
• Phill Lewis | voiced | Duper | 3 Episodes |
• Clancy Brown | voiced | Henry Fischer / Various / Convenience Store Clerk | 3 Episodes |
• Sy Smith | voiced | Unknown / Various | 3 Episodes |
• Shawn Michael Howard | voiced | Homeless Man / Various / Belmonpan | 3 Episodes |
• Jon Tenney | voiced | Lawyer #2 / Father Carrington / Norman | 3 Episodes |
• Molly Shannon | voiced | Christie White | 3 Episodes |
• Mae Whitman | voiced | Glitter / Denuda / Various | 3 Episodes |
• Patton Oswalt | voiced | Bob / Ticket Taker / Kenny Kiss Cam | 3 Episodes |
• J.K. Simmons | voiced | The Judge / Various / Mr. McCreary | 3 Episodes |
• Ron Livingston | voiced | Bob Memari | 3 Episodes |
• Azura Skye | voiced | Veronica / Various / Kristen | 3 Episodes |
• Wayne Brady | voiced | Tungee / Cuba Gooding Jr. / Delroy | 3 Episodes |
• Robert Tinkler | voiced | Clerk / Doyle / Various | 3 Episodes |
• Ivana Milicevic | voiced | Svetlana / Austrian Woman / Various | 3 Episodes |
• Karen Maruyama | voiced | Kichiro / Cocoa / Woman | 3 Episodes |
• Nat Faxon | voiced | Unknown / Strip Club Patron / Director | 3 Episodes |
• Melanie Deanne Moore | voiced | Harper / Various | 3 Episodes |
• Sinbad | voiced | Himself | 3 Episodes |
• Elizabeth Banks | voiced | Becky Arangino / Lisa Silver | 3 Episodes |
• Forest Whitaker | voiced | Ron Turlington | 3 Episodes |
• Don Tai | voiced | Qui Lo | 3 Episodes |
• Amy Sedaris | voiced | Dr. Meg Penner / Dr. Lizzy / Various | 3 Episodes |
• Ken Jeong | voiced | Dr. Perlmutter / Butch Johnson | 3 Episodes |
• Mariah Carey | voiced | Various / Laura / Replacement Waitress | 3 Episodes |
• Rolando Molina | voiced | Mex | 3 Episodes |
• Alan R. Cohen | voiced | Various | 3 Episodes |
• Pete Holmes | voiced | Various / Matt Davis | 3 Episodes |
• Timothy Taule | voiced | Unknown / Blonde Spy | 3 Episodes |
• Brian Lally | voiced | Nebraska Man / Amy's Father / Art Teacher | 3 Episodes |
• J. Lee | voiced | Leprechaun / Wesley Snipes / Various | 3 Episodes |
• Taryn Southern | voiced | Various | 3 Episodes |
• Michael Dunn (2) | voiced | Guard / Paramedic / Unknown | 3 Episodes |
• Randy Spears | voiced | John Q | 3 Episodes |
• Kamilah Marshall | voiced | Hershey Park Singer / Unknown | 3 Episodes |
• Max Charles | voiced | Various | 3 Episodes |
• Joe Chandler | voiced | Various / Joe Chandler | 3 Episodes |
• Eric Schermerhorn | voiced | Various | 3 Episodes |
• Tom Kenny | voiced | Jo-Jo | Slow Janitor / Various | 2 Episodes |
• Tim Kelleher | voiced | Unknown | 2 Episodes |
• Bryan Cranston | voiced | Mr. Winthrop / Bill Publisherman | 2 Episodes |
• Michael Pena | voiced | Margaritte | 2 Episodes |
• Marianne Muellerleile | voiced | Augustus' Mother / Unknown | 2 Episodes |
• Raven-Symone | voiced | Katie / Woman | 2 Episodes |
• Edward Asner | voiced | Grandpa Smith / Red Mailbox | 2 Episodes |
• Zuhair Haddad | voiced | Old Man | Police of Vice & Virtue #3 / Various | 2 Episodes |
• Elon Gold | voiced | Various | 2 Episodes |
• Gina Gershon | voiced | American Girl #1 / Karen | 2 Episodes |
• Sarah Michelle Gellar | voiced | Phyllis / Jenny | 2 Episodes |
• Jodi Long | voiced | Trung's Mom / Various | 2 Episodes |
• Missi Pyle | voiced | Various | 2 Episodes |
• Josh Groban | voiced | Whiny Parishoner / Himself | 2 Episodes |
• Beau Bridges | voiced | Lieutenant Thacker / Doctor | 2 Episodes |
• Kathy Griffin | voiced | Kelly / Herself | 2 Episodes |
• Ralph Garman | voiced | Hazmat Guy / Various | 2 Episodes |
• Debra Wilson | voiced | Whitney Houston / Various | 2 Episodes |
• David Hemingson | voiced | Bartender / Hercules | 2 Episodes |
• Brian Posehn | voiced | Dan Vebber | 2 Episodes |
• Catero Colbert | voiced | Derek Jeter | 2 Episodes |
• Jon Ross | voiced | Alien Man / Kurt | 2 Episodes |
• Grace Park | voiced | Akiko Yoshida | 2 Episodes |
• Andy Richter | voiced | Philip / Various | 2 Episodes |
• James Patrick Stuart | voiced | Eddie / Various | 2 Episodes |
• Cedric Yarbrough | voiced | Various / Security | 2 Episodes |
• Alyson Hannigan | voiced | Chelsey / Herself | 2 Episodes |
• D.D. Howard | voiced | Sheila | 2 Episodes |
• Emmanuelle Chriqui | voiced | Unknown | 2 Episodes |
• John Ennis | voiced | Tex | 2 Episodes |
• Rob Huebel | voiced | Unknown / Various | 2 Episodes |
• Phil LaMarr | voiced | Agent Crisp / Various | 2 Episodes |
• Grey Griffin | voiced | Akiko | 2 Episodes |
• Ron Perlman | voiced | Various / Colonel | 2 Episodes |
• Jay Thomas | voiced | Brett Morris | 2 Episodes |
• Danielle Schneider | voiced | Fairytale Land Princess / Nurse | 2 Episodes |
• Jon Cryer | voiced | Quacky / Chimdale Desk Clerk | 2 Episodes |
• Gary Anthony Williams | voiced | Cuban's Bodyguard / Various | 2 Episodes |
• Jenny Lewis | voiced | Various | 2 Episodes |
• Leslie Jordan | voiced | Mr. Beauregard | 2 Episodes |
• Thomas Lennon | voiced | Various | 2 Episodes |
• Scott Mosenson | voiced | Various | 2 Episodes |
• Michelle Krusiec | voiced | Nurse / Hooker / Various | 2 Episodes |
• Kat Dennings | voiced | Tanquarei / Various | 2 Episodes |
• Ellen Albertini Dow | voiced | Woman on Bus / Old Woman | 2 Episodes |
• Terry Crews | voiced | Ronnie / Heinrich Brown | 2 Episodes |
• Nathan Fillion | voiced | Liver / Various | 2 Episodes |
• Edward Herrmann | voiced | Unknown / Various | 2 Episodes |
• Ioan Gruffudd | voiced | Gabriel Byrne | Medic / Unknown | 2 Episodes |
• George Segal | voiced | Bernie / Various | 2 Episodes |
• Suzanne Cryer | voiced | Babette / Unattractive Girl #1 | Misty | 2 Episodes |
• Chad Brannon | voiced | Various | 2 Episodes |
• Jason Lee | voiced | Officer Bays | 2 Episodes |
• Jeremy Sisto | voiced | Mitch | 2 Episodes |
• Joe Lo Truglio | voiced | Freddy / Various | 2 Episodes |
• Elias Koteas | voiced | Jim | 2 Episodes |
• Zach Galifianakis | voiced | Norman | 2 Episodes |
• Peter Lurie | voiced | Man at Bizarre | 2 Episodes |
• Skyler Gisondo | voiced | Matty Moyer / Unknown | 2 Episodes |
• Harve Presnell | voiced | Judge | 2 Episodes |
• Chris Cox | voiced | George W. Bush / Unknown | 2 Episodes |
• Kim Parks | voiced | Various | 2 Episodes |
• Kristen Schaal | voiced | Girl / Librarian | 2 Episodes |
• Andrew Geller | voiced | Various | 2 Episodes |
• Zooey Deschanel | voiced | Pixie Dream Girl / Candy Striper | French Main | 2 Episodes |
• Joe Buck | voiced | Various | 2 Episodes |
• Anjelica Huston | voiced | Superintendent Ellen Riggs | 2 Episodes |
• Stark Sands | voiced | Tino | Conservative #1 / Williams | 2 Episodes |
• Brian George (1) | voiced | Ali | Prince | Guy #3 / Ali | 2 Episodes |
• Odile Corso | voiced | God / Angelina Jolie | 2 Episodes |
• Max Burkholder | voiced | Kid | 2 Episodes |
• Lew Schneider | voiced | Mr. Billdocker / Various | 2 Episodes |
• Terri Lyn Rodriguez | voiced | Unknown / Lindsay Coolidge | 2 Episodes |
• T.J. Miller | voiced | Audience Member / Cowboy | 2 Episodes |
• Dan Fogler | voiced | Unknown | 2 Episodes |
• Casey Wilson | voiced | Korean Woman / Various | 2 Episodes |
• Kasey Bell | voiced | Various | 2 Episodes |
• Adam DeVine | voiced | Various | 2 Episodes |
• Katie Crown | voiced | Various | 2 Episodes |
• Josh Robert Thompson | voiced | Various | 2 Episodes |
• Kat Purgal | voiced | Various | 2 Episodes |
• Dizzy Galette | voiced | Various / Tyler | 2 Episodes |
• Gabourey Sidibe | voiced | Party Girl / Herself | 2 Episodes |
• Anne Elizabeth Gregory | voiced | Zoe / Various | 2 Episodes |
• Dan Navarro | voiced | Cilantro / Various | 2 Episodes |
• Sawyer Ever | voiced | Boy in IHOP / Boy in Street | 2 Episodes |