| • Danny Smith (1) | voiced | Various / Antonio Monatti / Hotel Manager / Jim Kaplan / Harrison / Blackie / The Mass Media Murderer / Officer Horowitz / The Leper / Japanese Man / Bob Hope / Minister / Cop | Horse / A / Man #1 / Moby Dick / Paulie / Second Caterpillar | Suitor | T.V. Announcer / Alan Sherman Record / Sherriff / Buzz Killington / Loan Shark / Beer Can / Stephen King / Evil Monkey / Male Midget | Pink Panther / G.I. Jose / Barber / Himself / Mortician / Lawyer / Gynecologist / Albert | Captain Hook | 176 Episodes |
| • Patrick Warburton | voiced | Superman / Joe Swanson / Biggs Darklighter / Disney Coffee Pot | Quahog Human Catcher / Cal Johnson / Probe Droid / Jabba the Hutt / Various | 175 Episodes |
| • John Viener | voiced | Various / TV Executive | Apache Chief | FCC #1 / Announcer / Emcee / Announcer #2 | Ring Announcer | TV Announcer | British Man | British Woman / Chieftain / Joe / Bob Barker / Mr. Crates | TV Announcer / Morgan Freeman | Sylvester Stallone / Han Solo / Rocky Balboa | John Travolta / Hitler / Indiana Jones | Nick Nolte / Realtor / Priest / Rob / Morgan Freeman | Will Smith | McBurgertown Rep / Fjurg Van Der Ploeg | Various / New Brian / Ron / Announcer | Jagermeister | Lead Singer | Pilot / FOX Exec / Announcer | Chazz Palminteri | Radio Voice | Scientist / Derek Wilcox | Sting / Adolph Hitler / Madame Claude / Police Dog / Mark Wahlberg / Vladimir Putin / Video Store Clerk / Tony / British Radio Announcer / Kenneth Gould / Rodrico / Todd Goldstein / Abortion Video Spokesman / Derek Wilcox / Man in Coma / Franz Gutentag / Peter Griffin / Michael McDonald / Woman / King Henry VIII / Scott Greenberg / Mall Santa | Eeyore | Robot Notary / Lawyer | Agent Jessup / Marriage Counselor | Jodi Foster / Helicopter Pilot / The Butt | TV Announcer / Major General Captain | Pilgrim / Ezekiel / Super Friends Accountant | Ryan / TV Announcer / TV Announcer | Doctor | Devon / Fire Inspector / Tea Party Rally Speaker / Nielsen Rep / Doctor / Man in Bar / Police Chief / Buzz Lightyear / Husband | Secret Service Agent / Tour Guide / Indiana Jones / Harrison Ford | Josh / Gynecologist / Randall Even Battencourt / Mr. Stone / Bennigan's Employee / Lawyer / Agent #2 | Announcer | Pirate #1 / Noel | 172 Episodes |
| • Alec Sulkin | voiced | Caveman #3 / Tony Danza / Various / Construction Worker / Announcer #2 / Starbucks Guy / Robin Williams / Baseball Announcer #1 / Jesus Christ / Announcer | Co-Pilot | Jesus | Trekkie #3 / Jock #3 / B-Ryan | Justin-Bobby / Parole Board Officer / Alan Rickman / Floyd Wetherton / Belgard / Announcer / Negatron | Aragorn / Dan Rather / Himself / Waiter / Grocer | 128 Episodes |
| • Ralph Garman | voiced | Dustin Hoffman / Gene Rayburn / Various / Agent Jenkins / Ted Turner / Bernie / Archie Bunker / Gene Shalit / Number Three / Feilding | Lance / Fat Guy / Parishoner #1 / Caveman #1 / Guy #1 / Conductor | Reporter | Voice in Bushes / Manager / Scientist / Maitre'D / Cop / Editor / Director / Police Clerk / Ronald Lockhart / Jeff / Mexican Fart / Kathleen Turner / Maniac Pope | Pirate #2 | 123 Episodes |
| • Adam West | voiced | Mayor Adam West / Grand Moff Tarkin / Ace Merrill / Disney Mouse / Himself / Fairy GodMother / Various | 98 Episodes |
| • Seth MacFarlane | voiced | Glenn Quagmire | Carter Pewterschmidt / Roger | Wicket / William Wordsworth | Drunk Seagull / Stan Smith / Ben Affleck | Vincent van Gogh | Tom Tucker | Bear / Bob Saget / High School Student #2 / Osama bin Laden | FCC #2 | Congressman / Adzin / Log #2 | General Goatbanger / Dan Quagmire | Ida Davis / Glenn Quagmire | Ida Davis / Glenn Quagmire | Tom Tucker / Jake Tucker | Hitler / Tom Tucker / Glenn Quagmire / Glenn Quagmire | Carter Pewterschmidt | Tom Tucker / Dr. Elmer Hartman / Glenn Quagmire | Bill Clinton / Carter Pewterschmidt | Dr. Hartman / Glenn Quagmire | John Davidson / Glenn Quagmire | Pigeon / Leonardo da Vinci / Dr. Hartman | Carter Pewterschmidt / Glenn Quagmire | Dr. Hartman | Carter Pewterschmidt / Himself / Glenn Quagmire | Dr. Elmer Hartman / Glenn Quagmire | Charlotte Rae | Inspector Gadget | Pope | Roger | Stan Smith | Tom Hanks / Glenn Quagmire | Dr. Elmer Hartman | Tom Tucker / Carter Pewterschmidt / Glenn Quagmire | Dr. Hartman | Carter Pewterschmidt | Tom Tucker / Tom Tucker | Seamus | Jasper / Glenn Quagmire | Dr. Elmer Hartman | Chip / Glenn Quagmire | Dr. Elmer Hartman | Tom Tucker | Seamus | George | Marty / Glenn Quagmire | Terrorist / Glenn Quagmire | Cousin Earl | Dog | Lord Cadwallider | Superfluous Employee / Mickey McFinnigan / Jasper / Kevin Swanson / Glenn Quagmire | Kool Aid Guy | Roger Smith / Glenn Quagmire | Tom Tucker | Captain Kirk | Scotty / Glenn Quagmire | God / Glenn Quagmire | Santa / Cary Grant | Giant Rabid Housecat | 83 Episodes |
| • Johnny Brennan (1) | voiced | Various / Horace / Mort Goldman | Horace / Mort Goldman / Officer Reeses / Jawa / Zima Bottle / Scott / Lando Calrissian | 69 Episodes |
| • Chris Cox | voiced | Various / George W. Bush / Jeff Campbell / Ross Fishman / Waiter / Kirk Cameron / Higgins / Kent | 58 Episodes |
| • Lori Alan | voiced | Diane Simmons / CoCo / Imperial Reporter | 57 Episodes |
| • Phil LaMarr | voiced | Judge / Various / “N-Word” Jim / Exterminator / Minister / Ollie Williams / Donald / Black Guy | FCC #3 / Man / Detective Scrotes | Ollie Williams / Black Guy / Judge | Ollie Williams / Comedian | 52 Episodes |
| • Rachael MacFarlane | voiced | Various / Maid / Miss Watson / Margot Kidder / Jill / Olivia Fuller / Kate Capshaw | Britney Spears / Olivia / Airport Employee / Fat Chick / Sandy Olsson / Amber / Nun / Shelley Duvall / Sex Slave / Stripper / Woman / Sonja / 1920’s Woman / Hayley Smith / Protestor | 51 Episodes |
| • Alex Breckenridge | voiced | Christina / Sarah / Cybill Shepard / Various / Jane | Kate | Roxanne / Hot Date / Popular Kid #6 / Girl In Bar / Miss Emily / Wife | JoAnne Fuller / Woman | 44 Episodes |
| • Mark Hentemann | voiced | Chief McKenzie / Various / Army Reception / Opie / Caleb | Guy #1 / Wimpy / Live Studio Ostrich / Trekkie #2 / Holden Caulfield / Trucker / Himself | 44 Episodes |
| • Alex Borstein | voiced | Eva Braun / Adrian Pennino | Homeless Waitress / Librarian / Armando's Wife | Julia Roberts / Mother Superior / Edith Bunker / Mrs. Janetti | Lindsay | Russian Woman / Producer / Tricia Takanawa / Lucy Ricardo / Italian Mom / Female Midget / Batina / Airport Employee / Edison's Wife / Barbara Pewterschmidt | Librarian / Herself / Barbara Pewterschmidt / Wife / Tricia Takanawa | Mrs. Takanawa / Mikey's Mother / Spanish Mom | Helen Doogan / Allison / Charmisse / Barbara Pewterschmidt | Teacher / Tricia Takanawa | Old Woman / Tricia Takanawa | Middle Eastern Woman / Daycare Teacher / Lady Cadwillder | Nanny / Karen Parotta / Loretta Brown / Mrs. Claus / Barbara Pewterschmidt | Loretta Brown / Deborah Kerr / Mrs. Lapardo | 43 Episodes |
| • Jennifer Tilly | voiced | Bonnie Swanson | 43 Episodes |
| • Mike Henry (1) | voiced | Disney Skunk | Disney Witch / Cleveland / Consuela / Various / Herbert / Consuela | Herbert / Bruce / Bruce | Rallo / Bruce | Consuela | Herbert / Jabba's Gatekeeper | Rallo / Obi Wan | Greedo / Armando / Gardener / Cleveland | Consuela / Bruce | Consuela / Consuela | Pilot / Bruce | Announcer / Rallo / Himself / Bruce | RJ | 42 Episodes |
| • Wally Wingert | voiced | Various / Mr. Sloan / Dr. Kaplan / Ball Cleaner / Cameraman / Announcer #1 | Corner Man / U / Austin Powers | 37 Episodes |
| • Gary Cole | voiced | Various / Chairman / Principal Shepherd / Mike Brady / Cop / Priest | 36 Episodes |
| • Chris Sheridan | voiced | James William Bottomtooth / Man / Caveman / Half-Dead Fat Guy / Fish | Judge | Man / Prisoner #2 | Waiter / Blue Car / Elephant | James William Bottomtooth / Chugs / Various / Train Conductor / The Cat / Himself / Dan / Agent #1 | Cat Burglar | 36 Episodes |
| • Steve Callaghan | voiced | Operator / Various / James Dean / Employee / DirecTV Announcer / McBurgertown Manager / Mugging Victim / Himself | 35 Episodes |
| • Kevin Michael Richardson | voiced | Doug The Pimple / Various / Sebastian / Black Professor / Young Ray Charles / Fozzy / Jerome / Soundwave / Mean Joe Greene / Cleveland Brown Jr. / Tyrone / Jerome | Marvin Gaye / Cee-Lo Green | 34 Episodes |
| • Fred Tatasciore | voiced | Chevy Chase / Various / Arnold Palmer / Cobra Commander / Alec Baldwin | Crewman / Announcer | Father | Professor / Michael Eisner / Ernest Hemingway | Van Gogh / Police Chief / Inmate | Johnny Wind Chimes | Man at Podium | 33 Episodes |
| • Nicole Sullivan | voiced | Blonde Girl / Various / Mary Ingalls / Muriel Goldman / Drunk Chick / Faith | Pretty Woman | Tara / Receptionist / Girl in Bookstore / Louise | 26 Episodes |
| • Christine Lakin | voiced | Various / Joyce Kinney / Amanda Small | 23 Episodes |
| • Julius Sharpe | voiced | Various | 23 Episodes |
| • Seth Green | voiced | Dylan Flannigan / Home Supply Employee / Matt Damon | Tim / Rocky Dennis / High School Student #1 / Jake Ryan / Consuela's Relative / Eli / Log #1 / Neil Goldman | Jeremy / Neil Goldman / Cheerleader / Himself / Waiter / George Washington / Delivery Man / Baby | British Guard #2 | 22 Episodes |
| • Carrie Fisher | voiced | Angela / Mon Mothma | 21 Episodes |
| • Patrick Meighan | voiced | Ben Seaver / Unknown / Various | 17 Episodes |
| • Tara Strong | voiced | Meg (singing) / Various / Beth / Cindi / Amanda / Tatum | Zack / Android | 16 Episodes |
| • H. Jon Benjamin | voiced | Carl / Yoda / Bob Belcher | 15 Episodes |
| • Gary Janetti | voiced | Various | 15 Episodes |
| • Patrick Stewart | voiced | Captain Picard / Himself / Avery Bullock / The Black Cat / Dick Pump / Melvin Shiverman / Susie Swanson | 14 Episodes |
| • Lisa Wilhoit | voiced | Replacement Meg | Beth / Connie DiMico / Various / Beth / Girl #1 / Beth and Connie | 14 Episodes |
| • Max Burkholder | voiced | Kid / Calvin / Bobby Stalling / Various / Scotty | 14 Episodes |
| • Drew Barrymore | voiced | Mrs. Lana Lockhart / Jillian | 12 Episodes |
| • Emily Osment | voiced | Various | 12 Episodes |
| • Nana Visitor | voiced | Justin's Mother / Woman / Rita / Lottery Announcer / Nancy Pelosi / Kate's Mother | 12 Episodes |
| • Mae Whitman | voiced | Suzie / Popular Kid #3 / Various / Annaleigh Quagmire / Julie / Woman / Student | Young Girl | Zuzu | 12 Episodes |
| • Scott Grimes | voiced | Kevin Swanson / Singer / Steve Smith / Various | 11 Episodes |
| • Adam Carolla | voiced | Death | 11 Episodes |
| • Robert Wu | voiced | Mr. Washee-Washee / Various / Charles Yamamoto / Sensei / Moon | 11 Episodes |
| • Jeff Bergman | voiced | Fred Flintstone / Various / Fred Flintstone | Paul Sorvino / John Goodman | 11 Episodes |
| • Mike Barker (1) | voiced | Various / The Buff Guy / Smurf #2 / Flaherty | 10 Episodes |
| • Carlos Alazraqui | voiced | Mr. Jonathan Weed | 10 Episodes |
| • Kirker Butler | voiced | George W. Bush / First Caterpillar | Member of Symphony / Lincoln's Neighbor / Various | 10 Episodes |
| • Wellesley Wild | voiced | Various / Moroccan Fart / Himself | 10 Episodes |
| • Dee Bradley Baker | voiced | Various / Admiral Ackbar / Klaus Heissler / Owl | 9 Episodes |
| • Jackson Douglas | voiced | Vaccuum Repairman / Various / FOX Cameraman | 9 Episodes |
| • Jonathan Morgan Heit | voiced | Boy Who Cried Wolf / Child / Various | 9 Episodes |
| • James Burkholder | voiced | Kid | 9 Episodes |
| • Joey Slotnick | voiced | Dick Clark / Various / Bob | Carter | 8 Episodes |
| • Colin Ford | voiced | Randall / Kid / Various | 8 Episodes |
| • Butch Hartman | voiced | Various / Scout Leader | 8 Episodes |
| • Dave Boat | voiced | Hand #1 / Richard Gere / Rupert / Ben Stiller / Various | 8 Episodes |
| • James Woods | voiced | Himself | 7 Episodes |
| • David A. Goodman | voiced | Various / Jesus / Trekkie #1 / Himself | 7 Episodes |
| • Lucas Grabeel | voiced | Anthony / Various | 7 Episodes |
| • Barclay Deveau | voiced | Various / Patty | 7 Episodes |
| • Josh Robert Thompson | voiced | Various | 7 Episodes |
| • Will Sasso | voiced | Randy Newman / Todd / Various / Bernie the Hamster / Bobby Briggs | 6 Episodes |
| • Jon Daly | voiced | Various | 6 Episodes |
| • Frank Welker | voiced | Freddy / Megatron | 5 Episodes |
| • Stacey Scowley | voiced | Hope / Renee Zellweger / Various | 5 Episodes |
| • Charles Durning | voiced | Francis Griffin | 5 Episodes |
| • Debra Wilson | voiced | Sandy Belford / Whoopi Goldberg / Nurse / Whitney Houston / Various | 5 Episodes |
| • Natasha Melnick | voiced | Various / Ruth | 5 Episodes |
| • Christina Milian | voiced | Esther | 5 Episodes |
| • Marlee Matlin | played | Herself / Stella | 5 Episodes |
| • Kim Parks | voiced | Tonya / Various | 5 Episodes |
| • Hunter Gomez | voiced | Various / Chunk / Justin Bieber | 5 Episodes |
| • Conway Twitty | played | Himself | 5 Episodes |
| • Luke Adams (3) | voiced | Various / Singer / Club Manager | 5 Episodes |
| • Jerry Lambert | voiced | Various | 4 Episodes |
| • Jane Lynch | voiced | Dotty Campbell / Various | 4 Episodes |
| • Yvette Nicole Brown | voiced | Various | 4 Episodes |
| • D.D. Howard | voiced | Various / Jane Fonda / Carol Brady | 4 Episodes |
| • Bruce McGill | voiced | Santa / Various | 4 Episodes |
| • Mo Collins | voiced | Various / Book Club Lady 1 / Ms. Hobson / Gert | 4 Episodes |
| • Patrick Bristow | voiced | Various / Hector | 4 Episodes |
| • Michael Chiklis | voiced | Big Fat Paulie / Bronx Guy / Mechanic | Cartoony Crewman / Hennessey | 4 Episodes |
| • Julie Hagerty | voiced | Carol | 4 Episodes |
| • Camille Guaty | voiced | Donna / Gina / Puerto Rican Girl / Various | 4 Episodes |
| • Glenn Howerton | voiced | Co-Worker / Various | 4 Episodes |
| • Catherine Reitman | voiced | Various | 4 Episodes |
| • Don LaFontaine | voiced | FOX Announcer / Various | 4 Episodes |
| • Denis Martell | voiced | Santos / Various | 4 Episodes |
| • Sanaa Lathan | voiced | Donna Tubbs-Brown | 4 Episodes |
| • Chace Crawford | voiced | Paul / Various / Jock #2 / Luke | 4 Episodes |
| • Tatum Hentemann | voiced | Various / Kid | 4 Episodes |
| • Meredith Scott Lynn | voiced | Various / Girl | 3 Episodes |
| • Michael Dorn | voiced | Lieutenant Worf / Himself | 3 Episodes |
| • Jay Leno | played | Himself | 3 Episodes |
| • Bryan Cranston | voiced | Himself / Doctor Jewish | 3 Episodes |
| • Phyllis Diller | voiced | Thelma Griffin / Thelma | 3 Episodes |
| • Jay Mohr | voiced | Trevor / Logan / Joe Pesci | 3 Episodes |
| • Gene Simmons | voiced | Himself / Gene Simmons | 3 Episodes |
| • Frank Sinatra, Jr. | voiced | Himself | 3 Episodes |
| • Kerrigan Mahan | voiced | Various | 3 Episodes |
| • Haley Joel Osment | voiced | Various | 3 Episodes |
| • Wallace Shawn | voiced | Bertram | 3 Episodes |
| • Judy Greer | voiced | Various / Showgirl / Hope | 3 Episodes |
| • Alex Thomas | voiced | Various / Dolphin #1 | Dolphin #4 | 3 Episodes |
| • Wil Wheaton | voiced | Himself / Anti-Abortion Protester | 3 Episodes |
| • Bob Barker | voiced | Himself | 3 Episodes |
| • Michael Clarke Duncan | voiced | The Stork / Various | 3 Episodes |
| • Martha MacIsaac | voiced | Various | 3 Episodes |
| • Lacey Chabert | voiced | Meg | 3 Episodes |
| • Joe Flaherty | voiced | Various / Western Union Man / Vatican Delivery Man | 3 Episodes |
| • Brian Doyle-Murray | voiced | Luke / Various / Salty | 3 Episodes |
| • Anne Hathaway | voiced | Mother Maggie / Herself / Various | 3 Episodes |
| • Hank Azaria | voiced | Various / Apu | Chief Wiggum | Officer Lou | Moe | Dr. Nick | Carl Carlson | Comic Book Guy | 3 Episodes |
| • Ioan Gruffudd | voiced | Unknown / Various / Prince Charles | 3 Episodes |
| • Beth Littleford | voiced | Jane Kaczmarek / Various | 3 Episodes |
| • Olivia Hack | voiced | Various | 3 Episodes |
| • Mary Kay Bergman | voiced | Various | 3 Episodes |
| • Cary Elwes | voiced | Watson / British Guard #1 | Doctor | Valet / Various | 3 Episodes |
| • Ricky Blitt | voiced | Bob Doyle / Various / Cashier | 3 Episodes |
| • David Berry (1) | voiced | Bobby / Various | 3 Episodes |
| • Anne-Michelle Seiler | voiced | Robin Hood | Chrissy / Female Student | Little Girl / Woman | 3 Episodes |
| • Kara Vallow | played | Herself | 3 Episodes |
| • Tony Sirico | voiced | Vinny / Himself | 3 Episodes |
| • Rush Limbaugh | voiced | WTAT Tatooine's All Talk Radio Host / The Rancor / Himself | 3 Episodes |
| • Meredith Baxter | voiced | Herself / Elyse Keaton | 3 Episodes |
| • Joe Lomonaco | voiced | Weenie | 3 Episodes |
| • Ted Jessup | voiced | Various | 3 Episodes |
| • Joshua Rush | voiced | Various | 3 Episodes |
| • Jack Samson | voiced | Various | 3 Episodes |
| • Waylon Jennings | voiced | Himself | 2 Episodes |
| • Nancy Cartwright | voiced | Daffney / Bart Simpson | Todd Flanders | Nelson Muntz | Ralph Wiggum | 2 Episodes |
| • Omid Abtahi | voiced | Faisal / Mahmoud | 2 Episodes |
| • Jonathan Frakes | voiced | Commander Riker / Himself | 2 Episodes |
| • Mila Kunis | voiced | Meg Griffin / Herself | 2 Episodes |
| • Ashley Tisdale | voiced | Priscilla | 2 Episodes |
| • Shawn Pyfrom | voiced | Oliver | 2 Episodes |
| • Jessica Biel | voiced | Brooke | 2 Episodes |
| • Fred Willard | voiced | Dave Campell / Various | 2 Episodes |
| • R. Lee Ermey | voiced | Coach / General | 2 Episodes |
| • Ben Stein | voiced | Rabbi Goldberg | 2 Episodes |
| • Gilbert Gottfried | voiced | Mort Goldmen / Horse | 2 Episodes |
| • Dan Castellaneta | voiced | Homer Simpson / Homer Simpson | Barney | Squeaky Voiced Teen | Krusty the Clown | Hans Moleman | Abe Simpson | Blue-Haired Lawyer | Mayor Quimby | Kodos | 2 Episodes |
| • Robert Loggia | played | Himself | 2 Episodes |
| • Dwight Schultz | voiced | Various / Randall Fargus | 2 Episodes |
| • Erik Estrada | voiced | Officer Francis “Ponch” Poncherello / Officer Ponch | 2 Episodes |
| • Margaret Easley | voiced | Hand #2 / Various | 2 Episodes |
| • Michael McKean | voiced | Pawtucket Pat / Pengrove Pig | 2 Episodes |
| • Allison Janney | voiced | Teen People Editor / Crystal | 2 Episodes |
| • Tamera Mowry | voiced | Esther / Various | 2 Episodes |
| • Paula Abdul | voiced | Herself | 2 Episodes |
| • Gregory Jbara | voiced | Various / Nazi Soldiers | 2 Episodes |
| • Andy Dick | voiced | Himself | 2 Episodes |
| • Hillary Tuck | voiced | Cecila / Various | 2 Episodes |
| • Chris Diamantopoulos | voiced | Various | 2 Episodes |
| • Ted McGinley | voiced | Todd Meyers / Helicopter Rental Agent | 2 Episodes |
| • Paul Stanley | voiced | Himself / Various | 2 Episodes |
| • Alex Rocco | voiced | Soccer Mom / Bea Arthur | 2 Episodes |
| • Patrick Duffy | played | Bobby Ewing / Jack | 2 Episodes |
| • Rob Lowe | voiced | Stanford / Himself | 2 Episodes |
| • Helen Reddy | voiced | Herself | 2 Episodes |
| • Mary Scheer | voiced | Various | 2 Episodes |
| • Neil Patrick Harris | voiced | Barney Stinson | 2 Episodes |
| • Ricardo Montalban | voiced | The Cow / Khan | 2 Episodes |
| • Candice Bergen | voiced | Murphy Brown / Gloria Ironbox | 2 Episodes |
| • Mark DeCarlo | voiced | Jerry Orbach / Various | 2 Episodes |
| • LeVar Burton | voiced | Vern / Himself | 2 Episodes |
| • George Wendt | voiced | Norm Peterson | 2 Episodes |
| • Kaitlin Olson | voiced | Various / Brenda | 2 Episodes |
| • Seth Rogen | voiced | Himself | 2 Episodes |
| • Suzie Plakson | voiced | Various | 2 Episodes |
| • Ellen Albertini Dow | voiced | Elderly Woman | 2 Episodes |
| • David Lodge (2) | voiced | Various | 2 Episodes |
| • Bob Costas | voiced | Himself | 2 Episodes |
| • Hugh Laurie | voiced | Various / Dr. Gregory House | 2 Episodes |
| • Marina Sirtis | voiced | Herself / Commander Troi | 2 Episodes |
| • Faith Ford | voiced | Corky Sherwood | 2 Episodes |
| • Josh Radnor | voiced | Ted Mosby | 2 Episodes |
| • Laura Vandervoort | voiced | Various / Bridget | 2 Episodes |
| • Kate Rigg | voiced | Brandi | Esperanza / Lara Flynn Boyle | 2 Episodes |
| • Bill Maher | played | Himself | 2 Episodes |
| • Martin Savage | voiced | Various / Priest | 2 Episodes |
| • Richard Dreyfuss | voiced | Himself | 2 Episodes |
| • Connie Britton | voiced | Various / Herself | 2 Episodes |
| • Louise DuArt | voiced | Various / Melissa & Joan Rivers | 2 Episodes |
| • Anthony Skillman | voiced | Child Singer / Various | 2 Episodes |
| • Ryan Reynolds | voiced | Himself / Man | 2 Episodes |
| • Victoria Principal | played | Pamela Ewing / Amanda Rebecca | 2 Episodes |
| • Chevy Chase | voiced | Clark Griswold / Himself | 2 Episodes |
| • Peter Shin | played | Himself | 2 Episodes |
| • Fairuza Balk | voiced | Connie DiMico / Various | 2 Episodes |
| • Will Ferrell | voiced | Fisherman / Black Knight | 2 Episodes |
| • Wayne Collins (1) | voiced | Various / Basketball Player | 2 Episodes |
| • Julia Sweeney | voiced | Woman in Restaurant / Naomi Robinson | 2 Episodes |
| • Jack Sheldon | voiced | The Bill / “Vagina Junction” Conductor | 2 Episodes |
| • Lane Schnaitter | voiced | Various / Barbara Mandrell | Natalie Wood | 2 Episodes |
| • André Sogliuzzo | voiced | Various / French Waiter / Lee | 2 Episodes |
| • Tom Devanney | voiced | Various | 2 Episodes |
| • Bobby Lee | voiced | Asian Man | 2 Episodes |
| • Cate Blanchett | voiced | Penelope / Queen Elizabeth | 2 Episodes |
| • Liam Neeson | voiced | Himself | 2 Episodes |
| • Roy Scheider | voiced | Himself | 2 Episodes |
| • Cheryl Tiegs | voiced | Herself | 2 Episodes |
| • Tom Brady (1) | voiced | Himself | 2 Episodes |
| • Jim Parsons | voiced | Sheldon Cooper / Gayjacker | 2 Episodes |
| • Kat Foster | voiced | Carolyn | 2 Episodes |
| • Chris O'Dowd | voiced | Unknown / Guard | 2 Episodes |
| • Keir Gilchrist | voiced | Kyle / Various | 2 Episodes |
| • Jessica Barth | voiced | Various | 2 Episodes |
| • Jessica Stroup | voiced | Various / Denise | 2 Episodes |
| • Darrel Heath | voiced | Dolphin #2 | Dolphin #3 / Various | 2 Episodes |
| • Walter Murphy | played | Himself | 2 Episodes |
| • Ron Jones (1) | played | Himself | 2 Episodes |
| • Matthew Horne | voiced | Himself | 2 Episodes |
| • John Bunnell | voiced | Himself | 2 Episodes |
| • Karley Scott Collins | voiced | Abby | Little Girl / Child | 2 Episodes |
| • J. Lee | voiced | Black Forest Tree / Black Guy | 2 Episodes |
| • Chris Parson | voiced | Charlie Sheen / Various | 2 Episodes |
| • Jennifer Birmingham | voiced | Unknown | 2 Episodes |
| • Brad Goreski | voiced | Various | 2 Episodes |
| • Sara E.R. Fletcher | voiced | Various | 2 Episodes |
| • Kat Purgal | voiced | Various | 2 Episodes |
| • Candace Marie | voiced | Miley Cyrus | Hannah Montana / Beth | 2 Episodes |
| • Mike Desilets | voiced | Various | 2 Episodes |
| • Max Charles | voiced | Various / Timmy | 2 Episodes |
| • Ron Macfarlane | played | Himself / Various | 2 Episodes |
| • Brandon Richardson | voiced | Various | 2 Episodes |
USA)
