| Name (Sort) | Character (Sort) | |
| •Neil Patrick Harris | played | Himself (Host 2015) (1Eps.) |
| •Ellen DeGeneres | played | Herself (Host 2007/2014) (2Eps.) |
| •Seth MacFarlane | played | Himself (Host 2013) (1Eps.) |
| •Billy Crystal | played | Himself (Host 1990-1993/1997-1998/2000/2004/2012) (9Eps.) |
| •Anne Hathaway | played | Herself (Co-Host 2011) (1Eps.) |
| •James Franco | played | Himself (Co-Host 2011) (1Eps.) |
| •Alec Baldwin | played | Himself (Co-Host 2010) (1Eps.) |
| •Steve Martin | played | Himself (Host 2001/2003/2010) (3Eps.) |
| •Hugh Jackman | played | Himself (Host 2009) (1Eps.) |
| •Jon Stewart | played | Himself (Host 2006/2008) (2Eps.) |
| •Chris Rock | played | Himself (Host 2005) (1Eps.) |
| •Whoopi Goldberg | played | Herself (Host 1994/1996/1999/2002) (4Eps.) |
| •David Letterman | played | Himself (Host 1995) (1Eps.) |
| •Chevy Chase | played | Himself (Co-Host/Host 1987-1988) (2Eps.) |
| •Goldie Hawn | played | Herself (Co-Host 1976/1987) (2Eps.) |
| •Paul Hogan | played | Himself (Co-Host 1987) (1Eps.) |
| •Alan Alda | played | Himself (Co-Host 1986) (1Eps.) |
| •Jane Fonda | played | Herself (Co-Host 1977/1986) (2Eps.) |
| •Robin Williams | played | Himself (Co-Host 1986) (1Eps.) |
| •Jack Lemmon | played | Himself (Co-Host/Host 1958/1964/1972/1985) (4Eps.) |
| •Johnny Carson | played | Himself (Host 1979-1982/1984) (5Eps.) |
| •Dudley Moore | played | Himself (Co-Host 1983) (1Eps.) |
| •Liza Minnelli | played | Herself (Co-Host 1983) (1Eps.) |
| •Richard Pryor | played | Himself (Co-Host 1977/1983) (2Eps.) |
| •Walter Matthau | played | Himself (Co-Host 1976/1983) (2Eps.) |
| •Bob Hope | played | Himself (Host/Co-Host 1940-1943/1945-1946/1953/1955/1958-1962/1965-1968/1975/1978) (13Eps.) |
| •Ellen Burstyn | played | Herself (Co-Host 1977) (1Eps.) |
| •Warren Beatty | played | Himself (Co-Host 1977) (1Eps.) |
| •Gene Kelly | played | Himself (Co-Host 1976) (1Eps.) |
| •George Segal | played | Himself (Co-Host 1976) (1Eps.) |
| •Robert Shaw | played | Himself (Co-Host 1976) (1Eps.) |
| •Frank Sinatra | played | Himself (Host/Co-Host 1963/1975) (2Eps.) |
| •Sammy Davis, Jr. | played | Himself (Co-Host 1972/1975) (2Eps.) |
| •Shirley MacLaine | played | Herself (Co-Host 1975) (1Eps.) |
| •Burt Reynolds | played | Himself (Co-Host 1974) (1Eps.) |
| •David Niven | played | Himself (Co-Host 1958-1959/1974) (3Eps.) |
| •Diana Ross | played | Herself (Co-Host 1974) (1Eps.) |
| •John Huston | played | Himself (Co-Host 1974) (1Eps.) |
| •Carol Burnett | played | Herself (Co-Host 1973) (1Eps.) |
| •Charlton Heston | played | Himself (Co-Host 1973) (1Eps.) |
| •Michael Caine | played | Himself (Co-Host 1973) (1Eps.) |
| •Rock Hudson | played | Himself (Co-Host 1973) (1Eps.) |
| •Alan King | played | Himself (Co-Host 1972) (1Eps.) |
| •Helen Hayes | played | Herself (Co-Host 1972) (1Eps.) |
| •Jerry Lewis | played | Himself (Co-Host 1956-1957/1959) (3Eps.) |
| •Laurence Olivier | played | Himself (Co-Host 1959) (1Eps.) |
| •Mort Sahl | played | Himself (Co-Host 1959) (1Eps.) |
| •Tony Randall | played | Himself (Co-Host 1959) (1Eps.) |
| •James Stewart | played | Himself (Co-Host 1946/1958) (1Eps.) |
| •Rosalind Russell | played | Herself (Co-Host 1958) (1Eps.) |
| •Celeste Holm | played | Herself (Co-host 1957) (1Eps.) |
| •Claudette Colbert | played | Herself (Co-Host 1956) (1Eps.) |
| •Joseph L. Mankiewicz | played | Himself (Co-Host 1956) (1Eps.) |
| •Thelma Ritter | played | Herself (Co-Host 1955) (1Eps.) |
| •Donald O'Connor | played | Himself (Co-Host 1954) (1Eps.) |
| •Fredric March | played | Himself (Co-Host 1954) (1Eps.) |
| •Conrad Nagel | played | Himself (Host 1953) (1Eps.) |