•Dan Castellaneta | voiced | Homer Simpson, Abraham Simpson, Krusty the Klown, Barney, Willy, Sideshow Mel, Mayor Quimby, Hans Moleman, Gil, Itchy, Various (592Eps.) |
•Julie Kavner | voiced | Marjorie "Marge" Bouvier Simpson, Patty Bouvier, Selma Bouvier, Jacqueline Ingrid Bouvier, Various (592Eps.) |
•Nancy Cartwright | voiced | Bart Simpson, Nelson Muntz, Ralph Wiggum, Todd Flanders, Kearney, Various (592Eps.) |
•Yeardley Smith | voiced | Lisa Simpson, Various (592Eps.) |
•Hank Azaria | voiced | Apu, Moe, Chief Wiggum, Carl, Comic Book Guy, Dr. Nick Riviera, Prof. Frink, Cletus, Sea Captain, Kirk Van Houten, Various (S03+, Recurring Previously) (553Eps.) |
•Harry Shearer | voiced | Mr. Burns, Smithers, Dr. Marvin Monroe, Ned Flanders, Seymour Skinner, Otto, Kent Brockman, Dr. Hibbert, Lenny, Rev. Lovejoy, Various (588Eps.) |