Not Safe with Nikki Glaser will blend chats with comedians, pre-taped vignettes and social experiments. Glaser and her guests will share personal stories about sex, relationships and other taboo topics. Glaser's series promises to explore the current state of modern dating and be an outlet for viewers to find a frank, funny, and honest perspective on all things sex. The audience will also be encouraged to share their own potentially NSFW content with Glaser across multiple platforms.