Ayashi no Ceres follows Aya Mikage, who learns on her sixteenth birthday that she is the reincarnation of a celestial maiden named Ceres, and her twin brother Aki is the reincarnation of Ceres' former husband, Mikage.
When Ceres begins to manifest herself in Aya she must try to save her brother by finding Ceres' lost celestial robe, while trying to avoid being killed or captured by her own family who wants to use Ceres's incredible powers and abilities for their own gain.