Agent X centers on America’s first female Vice President, Maccabee (Sharon Stone), a woman with brains, beauty, and a cool composure that belies a restless mind. After the death of her husband, a Senate candidate, Natalie opted to run in his place, and after a rapid political rise, she now finds herself the newly elected Vice President of the United States. Initially apprehensive that her job will be ceremonial in nature, she soon learns that it comes with a top secret duty: protecting the Constitution in times of great crisis with the aid of her Chief Steward and a secret operative designated Agent X.