Set in present day Minneapolis, "A.M.P.E.D." centres on a group of police detectives and officers as they deal with a small but growing percentage of the population that is falling prey to strange genetic mutations, causing them to do destructive things to the city and those around them. Lee Tergesen has been cast in the lead role of Detective Brian Spicer, a sensitive and quick-thinking homicide officer who is legendary in the Department for being fearless and level-headed. Tony Curran portrays Detective Mark Jacocks, a tough cop who imparts his own special brand of survival philosophy onto rookies and whose method clashes with Spicer.