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Abby is distraught when she learns that her mentally troubled brother went missing while flying over the Great Lakes, a desperate Dr. Romano gets some depressing news and the hospital staff is confronted with a group of teenaged girls who are run down by a fellow female student suffering from a rare disease that might have caused the tragedy. Elsewhere, Dr. Chen's relationship with Dr. Pratt takes a new turn; a daughter wants to take extreme measures to keep her extremely elderly mother alive; Dr. Weaver gets a promotion from a grateful alderman and Dr. Lewis ponders her pending blind date with a hunk.
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